University of California, Riverside

Department of Nematology



Adler Dillman Faculty Page


Dr. Adler Dillman Adler R. Dillman

Assistant Professor of Parasitology
2107B Genomics
Office phone: (951) 827-3912
email: adlerd@ucr.edu

 

Lab Website

Biography

Dr. Dillman is from Orem, Utah and attended Orem High School. He has been interested in nematology since he was an undergraduate and joined the Society of Nematologists in 2004. His first interaction with UCR faculty was as an undergraduate; he was part of a soil ecology field trip, led by UCR, to the Republic of Moldova in 2005.  He has lived in California since beginning graduate school in 2007. He is happily married and has two sons. He joined the faculty in the Department of Nematology in 2015.

 

Education

2013-2014     Postdoctoral Fellow in microbiology and immunology,
                      Stanford University

2007-2013     Ph.D. in genetics, California Institute of Technology

2002-2006     B.Sc. in microbiology, Brigham Young University

 

Awards

2016     UCR Regents Faculty Fellowship.

2015     NIH NIAID K22 Career Transition Award.

2014     Howard Hughes Medical Institute Fellow of the Life Sciences
             Research Foundation.
             (3 year postdoctoral fellowship)

2013     Lawrence L. and Audrey W. Ferguson Prize (Caltech)

2012     John M. Webster Outstanding Student Award
             (Society of Nematologists and Nathan A. Cobb Foundation)

2012     Everhart Distinguished Graduate Student Lecturer Award
             (Caltech)

2009     Best poster in Ecology and Evolution, 2nd place award
             (Genetics Society of America)

 

Teaching

Biology 005A Introduction to molecular biology (Winter).

Biology 157 Parasitology (Fall).

 

Research Areas

We study host-parasite interactions from both perspectives, using insect hosts as models. Our interest is in how hosts recognize and initiate an immune response to parasites and how parasites evade and/or suppress immunity. We are working to identify and characterize effector molecules used by parasites to dampen host immunity or damage host tissue. Additionally, we also study parasite host-seeking behavior and olfaction using parasitic nematodes.  

From the host perspective we study how nematode parasites are recognized and the immune response that follows. To do this we use a variety of insect hosts. As part of this work, we study host immunity generally using bacterial pathogens, nematode parasites, and other immune insults. In studying immunity we differentiate the relative roles of resistance, the ability of the host to reduce or eliminate pathogen burden, and disease tolerance or the ability of the host to manage the effects of infections.

 

Publications
Selected Publications
(* equal contribution)

*Batugedara H.M., *Argueta D., *Jang J.C., Lu D., Macchietto M., Jaspreet K., Ge S., Dillman A.R., *DiPatrizio N.V., & *Nair M.G. Host and helminth-derived endocannabinoids are generated during infection with effects on host immunity. Infection and Immunity 2018.

Batugedara H.M., Chen G., Lu D., Patel J.J., Jang J.C., Radecki K., Burr A., Lo D.D., 
Dillman A.R., & Nair M.G. 2018. Bone marrow-derived RELMĪ± regulates hookworm immunity through effects on macrophage function. Journal of Leukocyte Biology 2018; 1-15.

Alonso V., Nasrolahi S., & Dillman A.R. 2018. Host-specific activation of entomopathogenic nematode infective juveniles. Insects 9, 59.

Serra L., Chang D., Macchietto M., Williams K., Murad R., Lu D., *Dillman A.R., & *Mortazavi A. 2018. Adapting the Smart-seq2 protocol for robust single worm RNA-seq. Bio-protocol 8(4): e2729.

Aryal S.K., Carter-House D., Stajich J.E., & Dillman A.R. 2017. Microbial associates of Scapteriscus borellii mole crickets are highly pathogenic. Journal of Invertebrate Pathology 150:54-62.

Kim I.-H., Aryal S.K., Aghai D.T., Casanova-Torres A.M., Hillman K., Kozuch M., Mans E., Mauer T.J., Ensign J.C., Gaudriault S., Goodman W.G., *Goodrich-Blair H., & *Dillman, A.R. 2017. Draft genome analysis and infection assays reveal that X. innexi, the mutualistic symbiont of entomopathogenic Steinernema scapterisci nematodes, encodes a mosquitocidal toxin but is attenuated for virulence in multiple insect models. BMC Genomics 18:927.

Baiocchi T., Lee G., Choe D.-H., & Dillman A.R. 2017. Host seeking parasitic nematodes use specific odors to assess host resources. Scientific Reports 7(1):6270.

Lu D., Macchietto M., Chang D., Barros M.M., Baldwin J., Mortazavi A., & Dillman A.R. 2017. Activated entomopathogenic nematode infective juveniles release lethal venom proteins. PLoS Pathogens 13(4):e1006302.

*Lu D., *Sepulveda C., & Dillman A.R. 2017. Infective juveniles of the entomopathogenic nematode Steinernema scapterisci are preferentially activated by cricket tissue. PLoS One 12(1):e0169410.

Lee J.H., Dillman A.R., & Hallem E.A. 2016. Temperature-dependent changes in the host-seeking behaviors of parasitic nematodes. BMC Biology 14:36.

Lu D., Baiocchi T., & Dillman A.R. 2016. Genomics of entomopathogenic nematodes and implications for pest control. Trends in Parasitology 32(8):588-598.

Dillman A.R. & Schneider D.S. 2015. Defining resistance and tolerance to cancer. Cell Reports 13: 884-887.

*Dillman A.R., *Macchietto M., Finlinson C.F., Rogers A., Williams B., Antoshechkin I., Lee M.-M., Goodwin Z., Lu X., Lewis E.E., Goodrich-Blair H., Stock S.P., Adams B.J., Mortazavi A., & Sternberg P.W. 2015. Comparative genomics of Steinernema reveals deeply conserved gene regulatory networks. Genome Biology 16:200. 

*Srinivasan J., *Dillman A.R., Mortazavi A., Antoshechkin I., Wong G. & Sternberg P.W. 2013. The genome and transcriptome of Panagrellus redivivus are shaped by the harsh demands of a free-living lifestyle. Genetics 193:1279-1295.

Dillman A.R., Guillermin M., Lee J., Kim B., Sternberg P.W., & Hallem E.A. 2012. Olfaction shapes host-parasite interactions in insect-parasitic nematodes. PNAS 109(35):E2324-E2333.

Dillman A.R. and Sternberg P.W. 2012. Entomopathogenic nematodes. Current Biology 22(11): R430-R431.

Dillman A.R., Chaston J.M., Adams B.J., Ciche T.A., Goodrich-Blair H., Stock S.P., & Sternberg P.W. 2012. An entomopathogenic nematode by any other name. PLoS Pathogens 8(3): e1002527.

More Information

General Campus Information

University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

Department Information

Department of Nematology
Margarita Flores
1447 Boyce Hall

Tel: (951) 827-3598
Fax: (951) 827-2364
E-mail: mverd003@ucr.edu

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